CV, Research Interests

Professor, Cardiovascular Center, Seoul National University Hospital, Seoul, South Korea, 03080

  Twitter: https://x.com/jkhan_mdphd

Jung-Kyu Han (@jkhan_mdphd) / X

 

  Google scholar: https://scholar.google.com/citations?hl=ko&user=0uhIrFgAAAAJ&view_op=list_works&sortby=pubdate

Jung-Kyu Han

 

 

■ Ongoing RCT:

HOST-PREVENTION: https://clinicaltrials.gov/ct2/show/NCT05845489?term=host-prevention&draw=2&rank=1 

Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis- CloPidogREl for Primary preVENTION (HOST-PREVENTION) - F

- To evaluate the efficacy and safety of clopidogrel for primary prevention in patients with subclinical coronary artery disease detected by imaging.

 

 

■ Previous RCT:

HOST-IDEA: https://clinicaltrials.gov/ct2/show/NCT02601157?term=host+idea&draw=2&rank=1 

Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - Coronary Intervention With Next Generation Drug-Eluting

1. To evalute the efficacy and safety of the abbreviated 3 month DAPT compared with the conventional 12 month DAPT after PCI using 3rd generation DES with ultrathin struts and advanced polymer techology.

- ACC 2023 Featured Clinical Research: Comparison Of 3-month Versus 12-month Dual Antiplatelet Therapy After Coronary Intervention Using The Contemporary Drug-eluting Stents With Ultrathin Struts And Advanced Polymer Technology: The Host-idea Randomized Clinical Trial

 

- Publication: https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064264

 

2. To compare two different 3rd generation DES platforms: Coroflex ISAR sirolimus-eluting stent (SES) vs Orsiro SES

- EuroPCR 2023 LBCT: Biodegradable polymer vs. polymer-free ultrathin sirolimus-eluting stents

 

- Publication: https://www.ahajournals.org/doi/abs/10.1161/CIRCINTERVENTIONS.123.013585

 

 

■ Main clinical interests: coronary intervention, coronary CTO, TAVR, peripheral intervention, EVAR

 

■ Main research interests: primary prevention, coronary intervention, basic reserach (direct conversion, endothelial aging)

 

 

■ Publications:

CORRESPONDING AUTHOR (Representative)

[3] You-Jeong Ki, Kyungdo Han, Hyo-Soo Kim, Jung-Kyu Han (corresponding). Smoking and cardiovascular outcomes after percutaneous coronary intervention: a Korean study. European Heart Journal 2023 [IF=39.3]

 

[2] You-Jeong Ki, Jeehoon Kang, Han-Mo Yang, Kyung Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, Myeong-Chan Cho, Chong-Jin Kim, Youngkeun Ahn, Myung Ho Jeong, Jung-Kyu Han (corresponding), Hyo-Soo Kim Immediate Compared With Delayed Percutaneous Coronary Intervention for Patients With ST-Segment-Elevation Myocardial Infarction Presenting ≥12 Hours After Symptom Onset Is Not Associated With Improved Clinical Outcome. Circulation: Cardiovascular Interventions 2021 14(5):e009863 [IF=7.514]

 

[1] Min Gyu Kong, Jung-Kyu Han (corresponding), Jee-Hoon Kang, Chengbin Zheng, Young Jin Choi, Eun-Seok Shin, Jang-Whan Bae, Kook-Jin Chun, Doo-Il Kim, Seung-Woon Rha, Sung Yun Lee, Jay Young Rhew, Seong-Ill Woo, Han Cheol Lee, Jin-Ok Jeong, Han-Mo Yang, Kyung Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, In-Ho Chae, Hyo-Soo Kim. Clinical outcomes of long stenting in the drug-eluting stent era: patient-level pooled analysis from the GRAND-DES registry. Eurointervention 2021 16(16):1318-1325 [IF=7.728]

 

 

THE 1ST AUTHOR (Representative)

[9] Jung-Kyu Han, Seokhun Yang, Doyeon Hwang, Sang-Hyeon Park, Jeehoon Kang, Han-Mo Yang, Kyung Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, Jin-Man Cho, Janghyun Cho, Duk Won Bang, Jae-Hwan Lee, Han Cheol Lee, Kyung-Jin Kim, Woo Jung Chun, Won-Woo Seo, Woo-Jung Park, Sang Min Park, Jin Won Kim, Hyo-Soo Kim. Biodegradable Polymer Versus Polymer-Free Ultrathin Sirolimus-Eluting Stents: Analysis of the Stent Arm Registry From the HOST-IDEA Randomized Trial. Circulation: Cardiovascular Interventions  2024 May 24:e013585 [IF=5.6]

 

[8] Jung-Kyu Han, Doyeon Hwang, Seokhun Yang, Sang-Hyeon Park, Jeehoon Kang, Han-Mo Yang, Kyung Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, Seung-Ho Hur, Weon Kim, Seok Yeon Kim, Sang-Hyun Park, Seung Hwan Han, Sang-Hyun Kim, Sanghoon Shin, Yong Hoon Kim, Kyungil Park, Namho Lee, Seung Jin Lee, Jin Won Kim, Hyo-Soo Kim. Comparison Of 3-6 Month Versus 12 Month Dual Antiplatelet Therapy After Coronary Intervention Using the Contemporary Drug-eluting Stents With Ultrathin Struts: The HOST-IDEA Randomized Clinical Trial. Circulation 2023 147(18):1358-1368 [IF=39.918]

 

[7] Jung-Kyu Han, Youngchul Shin, Hyo-Soo Kim. Direct Conversion of Cell Fate and Induced Endothelial Cells. Circulation Journal 2022 86(12):1925-1933 [IF=3.350]

 

[6] Jung-Kyu Han, Youngchul Shin, Min-Hwan Sohn, Saet-Byeol Choi, Dasom Shin, Youngrang You, Jong-Yeon Shin, Jeong-Sun Seo, Hyo-Soo Kim. Direct conversion of adult human fibroblasts into functional endothelial cells using defined factors Biomaterials 2021 272:120781 [IF=10.317]

 

[5] Jaehoon Chung, Jung-Kyu Han (co-1st author), Young Jo Kim, Chong Jin Kim, Youngkeun Ahn, Myeong Chan Cho, Shung Chull Chae, In‐Ho Chae, Jei Keon Chae, In‐Whan Seong, Han‐Mo Yang, Kyung‐Woo Park, Hyun‐Jae Kang, Bon‐Kwon Koo, Myung Ho Jeong, Hyo‐Soo Kim. Benefit of Vasodilating β‐Blockers in Patients With Acute Myocardial Infarction After Percutaneous Coronary Intervention: Nationwide Multicenter Cohort Study. Journal of the American Heart Association 2017 6. pii: e007063 [IF=4.450]

 

[4] Jung-Kyu Han, Back-Kyung Kim, Joo-Yun Won, Youngchul Shin, Saet-Byeol Choia, Injoo Hwang, Jeehoon Kang, Ho-Jae Lee, Seok-Jin Koh, Jaewon Lee, Jin Hur, Hyun-Jai Cho, In-Ho Chae, Byung-Hee Oh, Young-Bae Park, Hyo-Soo Kim. Interaction between platelets and endothelial progenitor cells via LPA-Edg-2 axis is augmented by PPAR-δ activation. Journal of Molecular and Cellular Cardiology 2016 97:266-277 [IF=4.874]

 

[3] Jung-Kyu Han, Sung-Hwan Chang, Hyun-Ju Cho, Saet-Byeol Choi, Hyo-Suk Ahn, Jaewon Lee, Heewon Jeong, Seock-Won Youn, Ho-Jae Lee, Yoo-Wook Kwon, Hyun-Jai Cho, Byung-Hee Oh, Peter Oettgen, Young-Bae Park, Hyo-Soo Kim. Direct Conversion of Adult Skin Fibroblasts to Endothelial Cells by Defined Factors. Circulation 2014 130:1168-1178 [IF=14.948]

 

[2] Jung-Kyu Han, Hack-Lyoung Kim, Ki-Hyun Jeon, Young-Eun Choi, Hyun-Sook Lee, Yoo-Wook Kwon, Ja-June Jang, Hyun-Jai Cho, Hyun-Jae Kang, Byung-Hee Oh, Young-Bae Park, Hyo-Soo Kim. Peroxisome proliferator-activated receptor-δ activates endothelial progenitor cells to induce angio-myogenesis through matrix metallo-proteinase-9-mediated insulin-like growth factor-1 paracrine networks. European Heart Journal 2013 34:1755-1765 [IF=14.097]

 

[1] Jung-Kyu Han, Hyun-Sook Lee, Han-Mo Yang, Jin Hur, Soo-In Jun; Ju-Young Kim, Chung-Hyun Cho, Gou-Young Koh, Jeffrey M. Peters, Kyung-Woo Park, Hyun-Jai Cho, Hae-Young Lee, Hyun-Jae Kang, Byung-Hee Oh, Young-Bae Park, Hyo-Soo Kim. PPAR-δ Agonist Enhances Vasculogenesis by Regulating Endothelial Progenitor Cells through Genomic and Non-genomic Activations of the PI3K/Akt Pathway. Circulation 2008 118:1021-1033 [IF=14.432]